PT-141 Users? Time of Day & Efficacy

Thread starter #1
I would like to hear from any PT-141 users that have had experience with different time of day injections. This drug has been a miracle for me...but also with mixed results.

Recently I injected at 10 pm right before bed. Woke up 2:00 am with raging erection. First time I ever started worrying about priapism but managed it with masturbation & walking around. Had partial wood on/off till the following afternoon. Needless to say, that disrupted my sleep too much but felt great too...like I was 16 again lol.

So from the same batch, 2 weeks later I injected 11 a.m. & it just never seemed to be anywhere near effective. A few randoms later in day but nothing even close to the last night time injection.

Now I wonder if somehow sleeping after an injection increases it's efficacy? Anyone else have similar experiences?

If sleep after an injection somehow increases it's efficacy, then maybe some experimenting is in order, i.e. take a nap after afternoon injection, inject in middle of night (during pee break) & ready for morning sex, etc.
 
#2
I found and read reports that 141 is rather iffy from one-time to the next, you can't use it regularly, either. The thing I think I remember the most was timing it around carbs but that might have been the GHRP2/6 I was using at the time. There was once or twice with 141 for me that I'd have obsessive sexual thoughts, then most other times, nothing at all. I think I had used up to 2mg at the end.
 
#4
I use Melanotan II at bedtime, the morning wood is off the hook most of the time. Also cialis daily, but I think its the Melanotan that brings on the morning wood so strong. So there may be something to what you are saying about sleep increasing the effects.
 
#5
I use Melanotan II at bedtime, the morning wood is off the hook most of the time. Also cialis daily, but I think its the Melanotan that brings on the morning wood so strong. So there may be something to what you are saying about sleep increasing the effects.
I know that they're very closely related but M2 isn't PT141.
 
Thread starter #8
I found and read reports that 141 is rather iffy from one-time to the next, you can't use it regularly, either. The thing I think I remember the most was timing it around carbs but that might have been the GHRP2/6 I was using at the time. There was once or twice with 141 for me that I'd have obsessive sexual thoughts, then most other times, nothing at all. I think I had used up to 2mg at the end.
That is why I posted this thread. My "iffy" results have always been when injecting during day or 3-4 hrs before sex. Those injections have had mixed results. But the injections before bed, those have consistently been awesome but then disruptive sleep & a sleeping partner are the drawbacks to having a raging hard on in the middle of the night :(

And I agree, I try to only use a couple times a month. Many have claimed it's efficacy reduces with frequent use. For me, I started low .5 mg & titrated up. I didn't get good results until 1.5 mg. I use 1.75 mg now & haven't tried anything higher.

Maybe my next daytime shot will be 2 mg to see if there is a difference. Guess I'm lucky in that I have never had nausea or flushing at any dose.
 
#9
Vince, let me try to clue you in as to why my post and observations regarding Melanotan II are relevant to the posters question. Melanotan II and PT-141 are both melanocortin agonists. Indirectly they are dopamine agonists. PT-141 was developed from Melanotan II in an attempt to isolate the erection and libido stimulating effects. So its pharmacodynamics are classified as more potent, and more selective in this regard. In actual research, your mileage may vary. So, PT-141 does not stimulate to the same degree the MC1 receptors that result in hyperpigmentation (and tanning) effect of Melanotan II. However, the means by which both stimulate erections is the same, and it is through neurologic modulation of MC receptors.

Now, the observation that these products work at their best to induce morning wood are not unique to this thread. You will see others report similar research findings. I will venture a theory on why this is the case. Getting an erection is neurologically induced by parasympathetic nerves. Since these products work on neurologic levels, the effect is most likely to provide the necessary parasympathetic lift to lead to an erection when our bodies are already in parasympathetic shift (during rest or deep sleep). The timing of the effect is usually observed to be about 6-7 hours, fairly closely coinciding with the deeper sleep cycles and the natural circadian timing of morning wood.

So that's why I contributed to the thread. I'm not looking for any credit but would like to avoid ignorant unnecessary remarks. I hope this helps explain things to those that are a bit too quick to criticize.
 
Thread starter #10
Thanks JPB for the informative reply. Some of what you wrote is over my head but still appreciate trying to learn.

So in your opinion is sleeping after dosing increasing the efficacy? Is it "mimicking" morning wood which why it seems less effective when dosed during day time?

P.S. I've never tried Trimix but the 10 pm inject & resulting 2 am raging wood, seemed to rival what I would expect from Trimix. First time I ever feared priapism lol
 
#11
So in your opinion is sleeping after dosing increasing the efficacy? Is it "mimicking" morning wood which why it seems less effective when dosed during day time?
Yes, although I wouldn't say it mimics morning wood but helps bring about the right neurological circadian effects to help it happen. Just a more robust, youthful pattern. This would be most likely during your normal (overnight) sleeping patterns, but could happen with a daytime nap, too I suppose. Really anything that induces a stronger parasympathetic shift will make erections more likely. But in this case there seems to be a pronounced sweet spot with these peptides and morning wood. In my research it seems the Melanotan II is a more cost effective option, I use it nightly. But you will get the hyperpigmentation and tanning effects, too.
 
#13
First time I took PT 141 I gave myself a shot of 1mg at 7:30 AM took the dogs for a walk took a shower and hit the gym everything I read said it would take 3 to 4 hours to take affect for me at the gym 2 1/2 hours after the shot started to get a raging hard on and had to leave before I could finish my sets got home wife is still asleep so I decided to make breakfast but couldn’t stop thinking about sex was driving me crazy the other bad thing air-conditioning wasn’t working and the temp was 96° she said it was too hot for sex needless to say I had a hard on for about eight hours and random hardons On and off through the night , Also had flushing for the first hour and a headache after around four hours . Was definitely crazy and wild will keep on doing it as long as the headaches aren’t as bad as the first time And definitely going to get the air conditioning fixed ha ha
 
Top