Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max

#22
I guess I just took the tone of this thread as it being a bad thing. I don’t see many downsides myself.
The tone was negative, but it's not a huge negative, limiting VO2 max, causing fatigue in some people which probably isn't noticed unless you work out with intensity.

It's really all about the anti-aging use of Metformin for people without impaired insulin control / disabilities. SHOULD healthy people take Metformin?

Clearly the benefits of Metformin for those with elevated blood glucose outweighs the problem that Metformin "inhibits mitochondrial adaptations to aerobic exercise training in older adults".

I had been taking 2x 500 ER metformin, my A1C was 5.8, in a month it went to 5.6, four days ago I measured it at 5.2. BUT I changed my diet and lost 18 lbs, so how much Met helped is debatable. It seemed to reduce my appetite for the first 20 lbs of weight loss, but now at least my appetite has returned to normal.

After the test, I quit taking Metformin, which is 4 days ago, I wanted to see how it affected my treadmill cardio and appetite control. So far my BG taken with a meter is OK, my cardio seems better. But I think the better test will be in a month to check A1C and then start Metformin again.

So I am certain with diet and exercise I can keep my A1C at 5.2, but not sure about how hard it will be to do that.

Long post, but IMO it's a little complicated.
 
#23
I’ve been on 500mg 2x day for about 3 weeks now. I’ll have to give my cardio a good test shortly here. So far I’ve not noticed a decrease but I haven’t pushed it hard either. If I sense a decrease in cardio ability I will cease use of metformin. I need my cardio at it’s absolute best for about 4 months of the year.

My a1c was 5.7 and 5.4 last 2 tests. I’ll be testing again in June. I feel leaner already but I’ve slightly cleaned up my diet. Not much though.
 
#24
1200 mg Leucine + 500 mg twice per day Metformin + probably 5 -10 mg sildenafil

I was using 500 mg twice per day of Metformin. Ordered some 25 mg viagra tablets to split them in 3. That is why I have not started. I got Leucine capsules from Amazon.
I started Met at 500mg 2x instant release about 6 weeks ago. At first it was amazing. Belly fat melted off, no bloating, I felt more relaxed and calm than normal, my flaccid hangs were bigger and relaxed, and had much improved erections (it helped more than Cialis every did and improved the effect of Cialis).

However about a week ago I started feeling super tired as well. I also got this muscle fatigue feeling, like my arms are heavy and muscles tight (maybe a little Lactic Acid?). At one point I was trying to use chopsticks and my hands were just not working well lol.

Anyways, I'm trying the EX version and just dosing 1x at night instead of the 2x per day. I'm hoping this might help as I don't want to stop. I had some fatty liver, lowish SHBG, etc., all signs of insulin resistance and metformin really helped a ton.

Anyone know if adding the leucine alleviated the fatigue? Any other things people are adding to help?
 
#26
Just an update - I lowered the dose to 500mg total per day and now have normal energy levels. I think I'm just sensitive to this drug. At 500mg a day I get the benefits but have normal levels of energy. Pretty stoked on that. I might even try taking 500mg every other day - basically taper down as much as possible while still getting the benefits.
 
#28
Just an update - I lowered the dose to 500mg total per day and now have normal energy levels. I think I'm just sensitive to this drug. At 500mg a day I get the benefits but have normal levels of energy. Pretty stoked on that. I might even try taking 500mg every other day - basically taper down as much as possible while still getting the benefits.
Curious as to what are the benefits you are seeing at that dose. Is there a measurable reduction in your serum glucose levels? Most adult males see no significant reduction in blood sugar levels at metformin doses below 1,500 mg./day.
 
Top