Low 17-OH Progesterone a concern?

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Gianluca

Well-Known Member
I was surprised 17-OH Progesterone was low <10 on LabCorp scale 27-199 ng/dl considering along with TRT I'was on
HCG 125Iu daily
50mg Pregnelonone
and 25mg of Hydrocotisone

I actually thought because I'm on Hydrocortisone Progesterone would be high(er)

Why would that be low?
 
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Nelson Vergel

Founder, ExcelMale.com
Yes, we blocked countries outside the US (except Canada and Mexico) since we kept getting bombarded by hackers. Our services are only good for the U.S.
 

Nelson Vergel

Founder, ExcelMale.com
Did you try a higher dose of hCG like the one used in studies (500 IU three times per week plus TRT) ?

Here is what the link said:

To find out if sperm count is normalized in men using hCG plus TRT, several studies have found that 17OH-P blood level is correlated to intratesticular testosterone (ITT) required for the testicles to make sperm, so testing for this hormone could not only save time while optimizing HCG dose/frequency but also eliminate the need to perform testicular aspirations, a very difficult procedure to do. Sperm count does not stabilize until 6-8 weeks after starting hCG plus TRT, so knowing your 17OH-progesterone blood level can give you a quick way to determine if your hCG dose and frequency is adequate.

This test uses liquid chromatography/mass spectrometry (LC/MS) the most accurate method for hormone testing.

The use of testosterone replacement therapy (TRT) increases blood levels of testosterone but, surprisingly, it decreases the level of testosterone inside the testicles (Intratesticular testosterone or ITT). ITT is key for proper sperm production. This ITT decrease is due to the LH and FSH shut down that occurs with TRT. This shut down decreases ITT and sperm production in men on TRT. These two gonadotropins are required to maintain healthy levels of ITT and, thus, sperm production. Some men on TRT become infertile because of this issue. ITT levels are usually ten times higher than regular blood levels. Having high testosterone blood levels on TRT have no positive effect on ITT. Only increasing LH or FSH can increase ITT. That is where hCG comes in...

Several studies have found that using human chorionic gonadotropin (hCG) while on TRT can normalize ITT and sperm production in some men (older age and longer pre-exposure to testosterone predicted poorer response). However, the optimum dose and frequency of hCG vary in every man. Fortunately, there are several ways to determine if the dose/frequency of hCG while on TRT is effective: Performing a sperm count/quality test (which requires a 3 month wait period) and/or measuring an upstream hormone to testosterone called 17-hydroxyprogesterone (17OH-P) (which can be measured within 2 weeks of starting hCG). TRT decreases 17OH-P and other upstream hormones due to the shut down of LH. Since hCG mimics LH, using hCG plus TRT may normalize upstream hormones like 17OH-P.

Several studies have found that 17OH-P blood level is correlated to ITT, so testing for this hormone could save time in optimizing HCG dose while waiting for a required 3-month sperm test. The 17OH-P test can also eliminate the need to perform testicular aspirations to measure ITT, which is a very difficult procedure to do and which is reserved to research settings. A study found that a 17OH-P level greater than 6.5 nmol/L (or 215 ng/dL) was found to normalize ITT while using HCG doses of 500 IU every other day plus testosterone enanthate injections given at 200 mg/week. However, only testing sperm count/quality after 3 months of hCG initiation makes it possible to know for sure if HCG is effective in improving fertility in men. As men get older and as they are exposed to longer periods on TRT, their response to HCG may decrease. These men may need combination approaches using clomiphene and/or FSH (follicle stimulating hormone).

References:

Amory et al. Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin suppressed normal men receiving various dosages of human chorionic gonadotropin. Fertility and Sterility. Vol. 89, No. 2, February 2008
 

Nelson Vergel

Founder, ExcelMale.com

 

Gianluca

Well-Known Member
Did you try a higher dose of hCG like the one used in studies (500 IU three times per week plus TRT) ?

Here is what the link said:

To find out if sperm count is normalized in men using hCG plus TRT, several studies have found that 17OH-P blood level is correlated to intratesticular testosterone (ITT) required for the testicles to make sperm, so testing for this hormone could not only save time while optimizing HCG dose/frequency but also eliminate the need to perform testicular aspirations, a very difficult procedure to do. Sperm count does not stabilize until 6-8 weeks after starting hCG plus TRT, so knowing your 17OH-progesterone blood level can give you a quick way to determine if your hCG dose and frequency is adequate.

This test uses liquid chromatography/mass spectrometry (LC/MS) the most accurate method for hormone testing.

The use of testosterone replacement therapy (TRT) increases blood levels of testosterone but, surprisingly, it decreases the level of testosterone inside the testicles (Intratesticular testosterone or ITT). ITT is key for proper sperm production. This ITT decrease is due to the LH and FSH shut down that occurs with TRT. This shut down decreases ITT and sperm production in men on TRT. These two gonadotropins are required to maintain healthy levels of ITT and, thus, sperm production. Some men on TRT become infertile because of this issue. ITT levels are usually ten times higher than regular blood levels. Having high testosterone blood levels on TRT have no positive effect on ITT. Only increasing LH or FSH can increase ITT. That is where hCG comes in...

Several studies have found that using human chorionic gonadotropin (hCG) while on TRT can normalize ITT and sperm production in some men (older age and longer pre-exposure to testosterone predicted poorer response). However, the optimum dose and frequency of hCG vary in every man. Fortunately, there are several ways to determine if the dose/frequency of hCG while on TRT is effective: Performing a sperm count/quality test (which requires a 3 month wait period) and/or measuring an upstream hormone to testosterone called 17-hydroxyprogesterone (17OH-P) (which can be measured within 2 weeks of starting hCG). TRT decreases 17OH-P and other upstream hormones due to the shut down of LH. Since hCG mimics LH, using hCG plus TRT may normalize upstream hormones like 17OH-P.

Several studies have found that 17OH-P blood level is correlated to ITT, so testing for this hormone could save time in optimizing HCG dose while waiting for a required 3-month sperm test. The 17OH-P test can also eliminate the need to perform testicular aspirations to measure ITT, which is a very difficult procedure to do and which is reserved to research settings. A study found that a 17OH-P level greater than 6.5 nmol/L (or 215 ng/dL) was found to normalize ITT while using HCG doses of 500 IU every other day plus testosterone enanthate injections given at 200 mg/week. However, only testing sperm count/quality after 3 months of hCG initiation makes it possible to know for sure if HCG is effective in improving fertility in men. As men get older and as they are exposed to longer periods on TRT, their response to HCG may decrease. These men may need combination approaches using clomiphene and/or FSH (follicle stimulating hormone).

References:

Amory et al. Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin suppressed normal men receiving various dosages of human chorionic gonadotropin. Fertility and Sterility. Vol. 89, No. 2, February 2008

after that I actually stopped the HCG and hydrocortisone, started a 100mg micronized capsule of Pregnenolone from Empower, and this time testing Progesterone, it came back at the upper end of scale, I did not test 17OH-Progesterone though. Although when I was using the 50mg Pregnenolone OTC, it was a micronized in a lipid matrix, that if I'm correct converts less to Progesterone because it by passes the liver.

Good thing you reminded me about this post, we can say 125IU daily of HCG did nearly 0 to increase upstream hormones.
 

Nelson Vergel

Founder, ExcelMale.com
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