High E2. Not sure I care.

Thread starter #1
I am having great results after switching from clomiphene to testosterone/hCG. Estradiol is elevated, but I am feeling good. Do I just hold the course if things are going well, even though E2 is 72.8?

Protocol for one month prior to labs was 50mg test cypionate and 250iu hCG every 2 days. I was doing Q3.5 days with higher equivalent dosages for 8 weeks before that, but having bad injection site reactions and changed to canola oil and more frequent dosing.

LABS
Pre-Clomiphene
Clomiphene/Anastrozole/DHEA
Testosterone/HCG/DHEA

Testosterone, Serum 305-->788-->886-->1105-->1084-->934-->1039

Free Testosterone(Direct) 5-->15.7-->16.3 -->19.4-->16.3-->20.6-->26.4

DHEA-Sulfate 106-->291.9-->253-->293.6-->600.5-->453.1

Estradiol, Sensitive 16.5 -->29.2 -->20.9-->29.7-->29.4-->28.5-->72.8

SHBG 42-->46.9-->44-->68-->63-->61.2-->38.4

T:E ratio 18.5 -->26.8-->41.43-->37-->36.8-->32.77-->14.3

Free T : Total T 1.6%-->2%-->1.8%-->1.76%-->1.5%-->2.2%-->2.5%
 
#2
It is very interesting that boosting your natural T did not raise your E2 but inject it to about the same lvl and all hell breaks loose. If you are not feeling this high E2 you probably shouldn't worry about it hell it could be a lab error they do that more than one would hope. If you end up losing your libido or develop ED or start putting on water weight, or become extra bitchy you will know the cause.
 
#3
I am having great results after switching from clomiphene to testosterone/hCG. Estradiol is elevated, but I am feeling good. Do I just hold the course if things are going well, even though E2 is 72.8?

Protocol for one month prior to labs was 50mg test cypionate and 250iu hCG every 2 days. I was doing Q3.5 days with higher equivalent dosages for 8 weeks before that, but having bad injection site reactions and changed to canola oil and more frequent dosing.

LABS
Pre-Clomiphene
Clomiphene/Anastrozole/DHEA
Testosterone/HCG/DHEA

Testosterone, Serum 305-->788-->886-->1105-->1084-->934-->1039

Free Testosterone(Direct) 5-->15.7-->16.3 -->19.4-->16.3-->20.6-->26.4

DHEA-Sulfate 106-->291.9-->253-->293.6-->600.5-->453.1

Estradiol, Sensitive 16.5 -->29.2 -->20.9-->29.7-->29.4-->28.5-->72.8

SHBG 42-->46.9-->44-->68-->63-->61.2-->38.4

T:E ratio 18.5 -->26.8-->41.43-->37-->36.8-->32.77-->14.3

Free T : Total T 1.6%-->2%-->1.8%-->1.76%-->1.5%-->2.2%-->2.5%
hard to argue with how you are feeling, but don't be too surprised if that all changes sometime soon.
 
#4
It's easier, in most cases, to reduce estradiol rather than work to raise it after it has been crashed. So...intervention of a subtle nature, if - probably when - it's called for. But, by all means, symptoms first.
 
#6
and of course 1 month is too early to get your system stabilised on testosterone injections w/HCG. You'll probably be able to reduce your dose once you get results after 40 days of being on testosterone / HCG injections.
 
Thread starter #7
and of course 1 month is too early to get your system stabilised on testosterone injections w/HCG. You'll probably be able to reduce your dose once you get results after 40 days of being on testosterone / HCG injections.
Just to clarify, I was injecting test for ~90 days before the labs. The last month of which I switched to EOD injections from Q 3.5d.
 
Last edited:
Thread starter #8
It is very interesting that boosting your natural T did not raise your E2 but inject it to about the same lvl and all hell breaks loose. If you are not feeling this high E2 you probably shouldn't worry about it hell it could be a lab error they do that more than one would hope. If you end up losing your libido or develop ED or start putting on water weight, or become extra bitchy you will know the cause.
Good points. I wonder if it was a lab error. I feel great and have no typical high E symptoms. I might even be less cranky than usual, sex drive is so high it's almost too much, and body comp. has improved quite a bit.
 
#9
any change in protocol with testosterone means your body needs 40 days to stabilise. Any labs before that 40 day period will change again.
 
Thread starter #10
hard to argue with how you are feeling, but don't be too surprised if that all changes sometime soon.
Could be. I was expecting some sort of a leveling out period with the change to injections, like I had with the clomid, but have been feeling very even. I have some anastrazole sitting on the shelf just in case I start getting the urge to shop for shoes though.
 
Thread starter #11
It's easier, in most cases, to reduce estradiol rather than work to raise it after it has been crashed. So...intervention of a subtle nature, if - probably when - it's called for. But, by all means, symptoms first.
Well put. I will be sure to go slow with any changes.

Anyone have thoughts on what to change first, when the time comes? Less test, less hCG, etc.? I know a subset of guys don't do well with hCG.
 
#12
Could be. I was expecting some sort of a leveling out period with the change to injections, like I had with the clomid, but have been feeling very even. I have some anastrazole sitting on the shelf just in case I start getting the urge to shop for shoes though.
Remember, women notice a gentlemans shoes, so don't underestimate the value of shoe shopping! In all seriousness, if your E2 is really that high, it's a really good chance that you'll have symptoms sooner than later. Best of luck.
 
#15
Good points. I wonder if it was a lab error. I feel great and have no typical high E symptoms. I might even be less cranky than usual, sex drive is so high it's almost too much, and body comp. has improved quite a bit.
Most likely explanation for one out of bounds test like this. I would retest and verify before doing anything.
 
Thread starter #17
I rested after another 5 weeks on my EOD protocol (9 weeks total) and numbers are all down. E2 is still high, but feeling pretty good.

Total T 861 (264-916)
Free T 20.9 (6.8-21.5)
E2 57.7 (8-35)

Trying to decide if I hold steady and retest in a few months or try some tweaks to see how it feels.
 
#18
I rested after another 5 weeks on my EOD protocol (9 weeks total) and numbers are all down. E2 is still high, but feeling pretty good.

Total T 861 (264-916)
Free T 20.9 (6.8-21.5)
E2 57.7 (8-35)

Trying to decide if I hold steady and retest in a few months or try some tweaks to see how it feels.
Leave it alone if you feel great. Gather those tests so you have lots of data associated with a protocol that works before you decide to tweak it. Wouldn’t worry about the e2 personally.
 
#20
I can understand why there would be concern. I haven’t seen anything too convincing one way or the other. It would have to be a study showing that test and e2 were kept in balance for years for me to care.

When they started giving women estrogen for years before they found out it was causing cancer they were careless and clueless. Progesterone and testosterone need to be in balance as well.

I don’t think the data is there for a conclusion.
 
Top