TL;DR: Some research suggests that echinacoside may complement a SERM in reducing TRT-induced negative HPT-axis feedback at the hypothalamus.
Background: In testosterone replacement therapy, elevated levels of testosterone and estradiol apply negative feedback to the hypothalamus. This...
TL;DR: It may be possible to improve results with bremelanotide by taking multiple daily micro-doses.
Like many, I have experimented with bremelanotide at the recommended doses, which range from a few hundred micrograms up to a couple milligrams in one subcutaneous injection. And also like...
I recently came across this article. It's not new, but the search function doesn't turn up previous discussions about it on ExcelMale.
Imbalance of testosterone/estradiol promotes male CHD development
Hong-Yun Zheng 1, Yan Li, Wen Dai, Chuan-Dong Wei, Kai-Sheng Sun, Yong-Qing Tong
Abstract...
Intriguing stuff, possibly highlighting another distinct cause of hypogonadism, along with a new treatment option. There's been little discussion of gonadotropin-inhibitory hormone or GnIH. This hormone counters kisspeptin and suppresses the HPTA. An excess of GnIH may lead to hypogonadism. RF9...
A tip of the hat to "PakMan" at PeakT for the reference to this article. The underlying work is on mice, but may have implications for humans.
Summary: Researchers have uncovered specific regions of brain tissue where aromatase is present, that drives male sexual desire. Aromatase converts...
TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men.
I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be...
TL;DR: Over a period of seven weeks, treatment with GnRH and enclomiphene raised LH and FSH from around 0.1 mIU/mL to about 1.0 mIU/mL, even though TRT and hCG dosing were continued. Subjective results have been encouraging.
I had written previously on the subject of GnRH suppression on TRT...
Admittedly the last thing we need is some other nebulous danger to worry about that may not even exist. Read on at your peril.
TL;DR: Testosterone replacement therapy suppresses the production of GnRH. Receptors for GnRH are found in places besides the pituitary. One animal model suggests GnRH...
Pre-treatment:
TSH: 2.8 (0.45 - 4.5 uIU/mL)
Free T3: 2.7 (2.0-4.4 pg/mL)
Free T4: 1.4 (0.82-1.77 ng/dL)
rT3: 23 (9.2-24.1 ng/dL)
I was prescribed liothyronine and told to start with 5 mcg/day and titrate up to a maximum of 20 mcg. I tried the 5 mcg dose for a couple weeks, then went to 10 mcg...
The relative level of SHBG has a pronounced effect on serum levels of testosterone delivered via TRT. This is through the influence of SHBG on the metabolic clearance rate of testosterone. But as far as I can tell the effect on the apparent half-lives of testosterone esters is subtle at best. Is...
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