Recent content by Cataceous

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    Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)

    Yes, enclomiphene reduces IGF-1. This was observed in the clinical trials, and I have experienced it as well. It's not necessarily a bad thing — with respect to longevity — if you end up only a little below average. But if you have other priorities, such as body building, then you'd probably...
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    Palmitoylethanolamide (PEA)

    As I recall it was in the range of 1-2 months. I think the standard advice is to give it 6 weeks before evaluating.
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    Palmitoylethanolamide (PEA)

    I've been taking 400 mg/d for three years now. I suspected I had some form of hyperalgesia, and using PEA correlated with a complete resolution of the issue. The possible amelioration of neurodegeneration also has some appeal. Taken together, the results reported here strongly suggest that by...
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    Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)

    Lack of acute toxicity does not imply long-term safety. Once you get north of 50 ng/mL there are negative correlations over time. Causality may not be firmly established, but why push upper limits without good reason? Interestingly, one study shows an inverted U-shaped curve for serum...
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    Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)

    I'm concerned about this patient's relatively low estradiol and excessive vitamin D. In terms of duration of action this product seems to lie between Natesto and oral testosterone undecanoate, perhaps better explaining why HPTA function can be preserved with the aid of enclomiphene. That's...
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    Is my free T too low? High SHBG

    That Quest free T number above is also a calculated value, not a result of equilibrium dialysis. Their calculation differs from the standard Vermeulen formula. The Vermeulen method is well studied and in my opinion is second only to properly performed equilibrium dialysis or ultrafiltration tests.
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    Is my free T too low? High SHBG

    Your Vermeulen calculated free testosterone is 13.4 ng/dL. This is healthy and I'd strongly advise against starting TRT with a level like this. The problems with TRT are frequently glossed over. When starting from normal levels the risks will usually outweigh possible benefits. TRT disrupts 20+...
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    HMG (Human Menopausal Gonadotrophin) Vrs HCG (Human Chorionic Gonadotrophin) - What’s the difference?

    It's called gonadotropin-releasing hormone or GnRH. The drug name is gonadorelin, and it is bio-identical. It does have a short half-life, which is essential for proper function. Long half-life analogs are actually used to shut down the HPTA. The problem is that pulsatile delivery is necessary...
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    Is your TRT Clinic a PILL MILL??

    Here's a reason: Federal Law: By way of the steroid Control Acts, applying to all federal courts, simple possession of anabolics [without a prescription] is a felony offense. First time offenders are subject to punishment of a minimum $1,000 fine and up to one year in prison. If the individual...
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    Maximus: Oral TRT+ (native T + enclomiphene + pregnenolone)

    I'm curious what changed their minds to now consider enclomiphene a viable component of the protocol. They were looking for alternatives after the FDA declined to add it to the 503A Bulks List. Maybe they are emboldened by Empower Pharmacy's continued production? Overall they give the sense of...
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    Testosterone and prosocial behavior

    I ponder that too as I watch shows like The First 48. Perhaps having a rough childhood alters the brain and/or its hormonal landscape in ways that dramatically reduce empathy. Having seen some striking changes accompanying regular low doses of oxytocin I'll speculate that this system is involved.
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    Testosterone and prosocial behavior

    Here's an old abstract that I found interesting because it tries to link aggression to the combination of high testosterone and low serotonin. It would be interesting to know if there has been followup work supporting the proposition. https://pubmed.ncbi.nlm.nih.gov/14509157/
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    First post. Can’t get E2 under control, starting to worry

    Wow. Totally speaks for itself. Yet you use those precious few minutes to write abusive drivel? I find it troubling that you are apparently a practicing physician. Pity the poor patient who questions anything you say.
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    First post. Can’t get E2 under control, starting to worry

    The principle is the same with exogenous testosterone. Instead of internal HPTA regulation of free testosterone there is external regulation via our control of the dose rate. Your example would get complicated if you're talking about injecting pure testosterone and DHT. But typically these...
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    First post. Can’t get E2 under control, starting to worry

    But it is exactly about reducing — available — SHBG. And the increase in free testosterone is a myth that doesn't want to die. Sure, in the short run if you start administering DHT then *transiently* this displacement occurs and free T briefly increases. But a steady state is soon reached and...
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