sermorelin and ipamorelin used together

[Another Great Day]

Sorry I meant to say: I have seen dosges of 300 to 350 mgms per day not per week.

I am new to peptide therapies. I spoke with Drfy last week and my order has been placed. Did you have a baseline IGF-1? May I ask how much did your IGF-1 increase on peptide therapy? I have seen the increase in clinical trials but rarely hear about the object results of IGF-1 increases with peptides on the internet.

 

[rafapark]

I am new to peptide therapies. I spoke with Drfy last week and my order has been placed. Did you have a baseline IGF-1? May I ask how much did your IGF-1 increase on peptide therapy? I have seen the increase in clinical trials but rarely hear about the object results of IGF-1 increases with peptides on the internet.

Yes, my IGF-1 was 100 in January 2018 and it is now 200. It has stayed at 200 since I'd say June 2018 after I used the CJC-1295/Ipamorelin combo. Once I moved to Defy and I switched to GHPR-2/Sermorelin it has not moved that much but that is a good number for me anyway I believe. The benefits I've seen, in combination with TRT, HCG, Lipotropics, supplements and a good diet and exercise has been a reduction of body fat % from 24% to 15%, a significant decrease in viceral fat and a significant increase in muscle. All my blood markers have improved ( except cortisol and prolactine, as mentioned below) Body comp measurements based on Dexa scans. And I was in decent shape (or I thought I was) before all this with a pretty good diet. I am 62 by the way.

The one thing I have found out is that these peptides have side effects, regardless of how minor they are, and I believe the CJC-1295/Ipamorelin is a much better peptide combination than the GHPR-2/Sermorelin with fewer side effects ( mainly water retention, cortisol and prolactine increase). I am by no means an expert and I suggest that you do your own research. Sometimes even advise from experience users in forums, including this one, could be miss leading for your particular case. The field of TRT and even more the field of peptides is evolving very quickly. If you read TRTs books from a few years back and you ask the same doctors today about some of the recommendations that they wrote back them they have changed their minds in some things. I'd go with Nelson's recommendation and start with Ipamorelin mono therapy if I were you and monitor your progress. Adjust based on that.

 

[Another Great Day]

That is a fantastic change in your IGF-1 and your body composition - congratulations and thank you for sharing. May I ask what dose you used with the CJC-1295/Ipamorelin combo? I have made a call to find out if the Sermorelin 1000mcg daily is correct but based upon Nelson's information I am going a different direction. I have also used a Dexa (local company is Dexafit) in my area and am getting tested this Friday as a baseline prior to beginning Ipamorelin.

 

[rafapark]

Sermorelin 1000 mcgs seems like a lot for a daily dosage. I am moving away from Sermorelin by way as there are much better peptides available in my opinion. I will use Ipamorelin monotherapy as Nelson suggests or go back to CJC-1295/Ipamorelin combo. Too back Defy does not sell this combo. I used 400 mcgs of the combo 5 days a week with two days off as recommended by my doctor back them. IGF-1 went up pretty quickly by the way. If you are going this route, I recommend you get it from a reputable compounding pharmacy through a clinic, not directly from the internet as you want to make sure of the purity. I also use Dexafit by the way, for my scans, out of Boca Florida.

 

[Another Great Day]

In my search I contacted Absolute pharmacy. They carry Ipamorelin CJC1295 Lyophilized 15/6mg in a 10ml vial for $299. They, like Empower, require a prescription.

 

[rafapark]

In my search I contacted Absolute pharmacy. They carry Ipamorelin CJC1295 Lyophilized 15/6mg in a 10ml vial for $299. They, like Empower, require a prescription.

That is why you need get it through a clinic. Usually they'd charge you between $280 to $330 or so for a month supply of Ipamorelin CJC1295 combo or 20 doses at 400 mcg which would includes consultation and such. Or get the mono therapy from Defy. Or maybe Defy would give you the prescription? Worth to ask. Let me you.

 

[Guided_by_Voices]

I think the issue is what is the maximum effective dose per injection, so 300 per day might be reasonable spread over two or three injections

 

[Another Great Day]

Absolute is a compounding pharmacy located in Florida. I would assume Defy could provide Absolute with the prescription and fill that prescription the same as Empower.

 

[rafapark]

Absolute is a compounding pharmacy located in Florida. I would assume Defy could provide Absolute with the prescription and fill that prescription the same as Empower.

There are a number of other reputable compounding pharmacies that I know that also sell this compound. Tailor Compounding out of Kentucky and Wells Pharmacy out of Ocala, FL. Let me know if you could get a prescription from Defy.

 

[Another Great Day]

I will give them a call today 1-3-19

 

[Another Great Day]

Today I heard back from Defy. They currently do not prescribe Ipamorelin+CJC1295 due to the lack of clinical data.

I requested from Defy the clinical reference points for the origin of this post, sermorelin 1000mcg sq nightly in combination with ipamorelin 360 mcg sq nightly.

 

[rafapark]

so they did confirm 1000 mcg of Sermorelin? That is a lot. I don’t inject that much sermorelin when I inject the GHRP-2/Sermorelin blend. That stack they are recommending will run more then $400 per month! right? Something doesn’t match. I am having my appointment with Defy tomorrow and will ask.

 

[Another Great Day]

I have been very happy with Defy's customer service and with my consultation with Dr. Saya. They are currently researching the 1000 mcg sermorelin. A new question goes up the chain: front desk, medical specialists, then to MD. They are very prompt in returning calls. My order from Empower is scheduled for delivery tomorrow. I am only starting ipamorelin at this time.

 

[rafapark]

I got my call with my Defy doc today. We discussed peptides. One thing that caught my attention was his remarks that these peptides might increase glucose. That I did not know. I was wondering on why my fasting blood glucose has gone up to the mid 90s despite my very strict low carb diet and BG in the low 80s before starting peptides. It is worth monitoring. He suggested to cycle off peptides for 4 weeks. I will do so an monitor my BG. We however discussed dosage for Ipamoraein/Sermorelin and he suggested 400 mcg of each combined in the same syringe when I decide to start. This will be $305 per month according to my calculations for 30 days. I am not sure it is worth it. I might do Ipamorelin monotherapy when I start back or CJC 1295/Ipamorelin blend, 400mcg which is a better combo for a lower price ( 5 days on, 2 days off) from a local clinic. I started with this combo and dosage, 5 days on, 2 days off back in April last year for two months before moving to Defy and my IGF-1 went from 100 to 190 in 6 weeks so it is effective with no BG impact. I did felt best with that combo too.

 

[Another Great Day]

Interesting about the increase in glucose with peptides. I heard back today about the sermorelin+ipamorelin. The response was that semorelin is similar to CJC 1295, that was the reason for the combination. I have yet to see this combination at these dosages in my google searches. I started ipamorelin 350 mcg yesterday. Once that is finished I am inclined to begin ipamorelin+CJC1295. Your results are amazing. Likewise, I have not seen the 5 on and 2 off treatment but it worked well for you, I may also copy that protocol.

 

[rafapark]

Interesting about the increase in glucose with peptides. I heard back today about the sermorelin+ipamorelin. The response was that semorelin is similar to CJC 1295, that was the reason for the combination. I have yet to see this combination at these dosages in my google searches. I started ipamorelin 350 mcg yesterday. Once that is finished I am inclined to begin ipamorelin+CJC1295. Your results are amazing. Likewise, I have not seen the 5 on and 2 off treatment but it worked well for you, I may also copy that protocol.

CJC 1295 is similar to Sermorelin but it is improved. Both have 29 amino acids. CJC 1295 is referred as modifed GRF (1-29). Modified GRF (1-29) is changed as compared to Sermorelin in that it has four substituted aminos in its chain that serve the purposes of preventing degradation and oxidation in manufacture and transport as well as in vivo, while also increasing binding affinity to the GHRH receptors. I am not sure why Empire doesn't have it as it has been around for a while at it is available at several other compounding pharmacies.

 

[Another Great Day]

What are your thoughts. I have already ordered the Ipamoreli and Sermorelin. Run Ipamorelin alone for 4 months, get dexa and lab tests to determine body composition changes and IGF-1. Then run the Ipamorelin+Sermorelin 4 months and repeat testing to see what changes have taken place.

 

[rafapark]

What are your thoughts. I have already ordered the Ipamoreli and Sermorelin. Run Ipamorelin alone for 4 months, get dexa and lab tests to determine body composition changes and IGF-1. Then run the Ipamorelin+Sermorelin 4 months and repeat testing to see what changes have taken place.

Hi. I am not sure if I know enough about this to give advice like that. I know that Igf-1 will increase pretty quick at least that was my case. Body composition will take longer. If I were you I’d go with the Ipamorelin monotherapy as Nelson suggests and monitor bloods in 6 weeks for Igf-1 and a Dexa scan in 6 to 8 months. As Igf-1 increases the rest is a lot of hard work. I assume that you are eating a pretry clean diet and working out accordingly. Look at Jay Campell’s “Blow torch diet” for guidance on diet and workouts. Everybody is different so you need to find what works for you. Also read Jay’s TOT bible which has great info on all this. Neither peptides nor Testosteone are silver bullets. They are just components of a greater plan on health and antiaging.

 

[Another Great Day]

I will check out those references - Thank you,

 

[Another Great Day]

Doing some research for the future. This morning I went to the website of NuImageMedical.com. They offer Ipamorelin + CJC 1295 15 mg vial plus a 30 ml bacteriostatic water for $199 per month when you sign up for a 3 month supply. This product is produced at Absolute compounding pharmacy.