Trough/Peak Values and Testosterone/E2 Ratio

For the past nine weeks I've been injecting 60mgs of test enth every 3.5 days.

Results on a "peak" (24 hours after injection injection):

Total Test: 1035 ng/dL (348 - 1197)

Free Test: 20.3 pg/mL (7.2 -24.0)

Estradiol (Sensitive LC/MS/MS): 55.6 pg/mL (8.0-35.0)

SHBG: 27.3 nmol/L (19.3-76.4)

Results on a "trough" (just prior to injection):

Total Test: 733 ng/dL (348 - 1197)

Free Test: 14.0 pg/mL (7.2 -24.0)

SHBG: 22.8 nmol/L (19.3-76.4)

Estradiol (Sensitive LC/MS/MS): 31.8 pg/mL (8.0-35.0)

Even on twice-weekly injections I clear testosterone more quickly than I'd like, but I feel great.

The estradiol level might suggest concern, but applying the ratio that Nelson and others use as a factor in evaluating e2 puts me in a comfortable spot at the peak and only slightly above the suggested value at the trough. As noted, I do fee good. Would you agree that there is NO NEED for an AI? I would think any adjustments could be made by pulling the total test dose from 60mg twice-a-week to 40mg. But I'm inclined to leave as things as they are, enjoy how I'm feeling, listen to my body, and test regularly.

But I would appreciate any thoughts as to this approach.

Most men don't need an AI especially on the dosages you are on.

Your labs look fine to me.

You can try not using the AI for 6 weeks and see how you feel.

If you get symptoms of elevated E2 or labs confirm elevated serum levels then just restart on the AI.

I'd give it a shot.

Gene Devine said:

Most men don't need an AI especially on the dosages you are on.

Your labs look fine to me.

You can try not using the AI for 6 weeks and see how you feel.

If you get symptoms of elevated E2 or labs confirm elevated serum levels then just restart on the AI.

I'd give it a shot.

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Never used an AI, and my doctor isn't keen on them if they can be avoided (though she'll prescribe if needed). My estradiol when I began therapy was single digit; a bone density scan as there was concern about osteopenia. It had not developed.