Another Study Review Debunks Two Prior Flawed Papers That Linked Testosterone and Heart Attacks

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Can Urol Assoc J. 2014 May-Jun; 8(5-6): E356–E357.
Published online May 21, 2014. doi: 10.5489/cuaj.1962

PMCID: PMC4039601


A critical analysis of testosterone supplementation therapy and cardiovascular risk in elderly men

Jason Scovell, BBA,* Ranjith Ramasamy, MD,* and Jason R. Kovac, MSc, MD, PhD, FRCSC†


Hypogonadism has become a common diagnosis in elderly men, with increasing prevalence from 20% in the sixth decade of life to 50% in the ninth.1,2 Declines in serum testosterone affect up to 40% of men;3,4 about 3.75% of men ≥60 years of age are on some form of testosterone supplementation therapy (TST).3,5–7
The use of TST in elderly men has been justified given that hypogonadism is an independent risk factor for cardiovascular disease and all-cause mortality.8–11 Furthermore, improvements following TST in body weight, waist circumference,12–18 HbA1c,17,19 and total cholesterol levels17,18contribute to decreases in cardiovascular adverse events (CVAEs). However, several recent population-based studies have raised concerns regarding the safety of TST in elderly (≥65 years old) men.20–23


The first study to identify an association between TST and cardiovascular risk was the Testosterone in Older Men (TOM) trial.20 The TOM trial was designed to evaluate muscle strength improvements in men aged ≥65 years (n = 209) with limited mobility. The authors included frail men with mobility limitations, including difficulty walking 2 blocks or climbing 10 steps.20 Since the study was designed to examine strength improvements, treatment was solely based on serum total testosterone and free testosterone values without considering hypogonadal symptoms.20 The trial was halted due to CVAEs ranging from elevated blood pressure (n = 3) and peripheral edema (n = 5) to stroke (n = 1) and myocardial infarction (MI) (non-fatal n = 2, fatal n = 1).20 The greatest concerns arose given the increased number of CVAEs in men on TST (n = 23) compared to placebo (n = 5).20 While drawing attention to the use of TST in elderly men, the TOM trial was not designed to address CVAEs. Furthermore, there were no differences in the number of serious, life-threatening adverse events between the testosterone and placebo arms of the study. Given that many men reached supra-physiological levels of serum testosterone, and a disproportionate amount of CVAEs occurred in these patients, correlates were drawn.


Recently, several studies have examined the relationship between CVAEs and TST in more detail. For example, a meta-analysis by Xu and colleagues24 noted an increased risk of CVAEs in men on TST (odds ratio 1.54, p < 0.05). Another large (n = 8709) retrospective national cohort study in elderly males (&#8805;60 years old) analyzed TST outcomes in hypogonadal men (serum testosterone <300 ng/dL) with previous coronary angiography.22 In this study, men who began TST had an absolute risk increase of 5.8% (p < 0.05) for a CVAE when compared to matched peers not receiving TST.22 Unfortunately, one of the major drawbacks of the study was that despite TST, most men remained hypogonadal (mean serum testosterone 332.2 ng/dL; delta = 175.5 ng/dL from baseline).22Furthermore, 17.6% of patients in the testosterone group filled only 1 prescription and no testosterone levels were measured after therapy, which raised the question of therapy adherence and the generalizability of the findings.
In another study, Finkle and colleagues21 determined that men &#8805;65 years old had an increased risk of non-fatal MI within 90 days of TST initiation. In this trial, the pre-TST prescription MI-event rate in men &#8805;65 years old was 5.27 (95% confidence interval CI] 3.81&#8211;7.27).21 Following the start of TST, these rates increased to 11.52 (95% CI 7.43&#8211;17.86) in men &#8805;65, while men <65 did not change (pre-TST MI-event rate of 3.22 CI 2.75&#8211;3.77 vs. post-TST MI-event rate of 3.76 CI 2.81&#8211;5.04).21 Unfortunately, in this population-based study, the lack of evaluation of serum hormones and hematocrit levels significantly limited the validity of the conclusions regarding the relationships between TST, serum testosterone and MI. In addition, men on TST were compared to men using PDE5 inhibitors, which is potentially confounding since PDE5 inhibitors benefit men with coronary artery disease, hypertension, heart failure, pulmonary arterial hypertension, and diabetes mellitus.25

Currently, the exact mechanisms for increased CVAEs in men on TST remain unknown. Testosterone stimulates erythropoiesis in a dose-dependent manner &#8211; an effect that is more prominent in elderly men.26TST also induces a hyper-coagulable state via increases in thromboxane A2 and platelet thromboxane A2 receptor density with decreases in prostaglandins.27 In the Tampere Adult Population Cardiovascular Risk study (TAMRISK), the authors demonstrated a relationship between borderline polycythemia and an increased risk of cardiovascular mortality.28,29 Taken together, it is tempting to speculate that TST may exacerbate cardiac risks in men with atherosclerosis by increasing blood viscosity and platelet counts leading to CVAEs in susceptible elderly patients.

A further factor to consider is the level of serum testosterone in the aging male since it appears that both sub-, and supra-physiological levels of testosterone carry risk. This was illustrated in the population-based cohort study recently done on 3690 men.30,31 The authors found that men whose serum testosterone was in the middle 2 quartiles (Q2 and Q3; testosterone 283 ng/dL to 453 ng/dL) of the population had the lowest incidence of death from any cause (Q2 vs. Q1, adjusted hazard ratio
0.82; Q3 vs. Q1, HR 0.78; Q4 vs. Q1, HR 0.86).30

In summary, the preponderance of the evidence suggests that TST should be used judiciously in elderly males, with a paradigm focused on returning serum testosterone levels to normal limits, rather than treating with supra-physiological doses (i.e., injections). Furthermore, it is essential to choose the proper TST modality and to schedule regular (i.e., every 3 months) visits to monitor hematocrit, platelet and serum estradiol levels with an experienced TST specialist.

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Footnotes

Competing interests: Dr. Scovell, Dr. Ramasamy and Dr. Kovac all declare no competing financial or personal interests.
This paper has been peer-reviewed.


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References

1. Harman SM, Metter EJ, Tobin JD, et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab. 2001;86:724&#8211;31.http://dx.doi.org/10.1210/jcem.86.2.7219. [PubMed]
2. Surampudi PN, Wang C, Swerdloff R. Hypogonadism in the aging male diagnosis, potential benefits, and risks of testosterone replacement therapy. Int J Endocrinol. 2012;2012:625434. [PMC free article][PubMed]
3. Mulligan T, Frick MF, Zuraw QC, et al. Prevalence of hypogonadism in males aged at least 45 years: The HIM study. Int J Clin Pract.2006;60:762&#8211;9. http://dx.doi.org/10.1111/j.1742-1241.2006.00992.x.[PMC free article] [PubMed]
4. Wu FC, Tajar A, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med.2010;363:123&#8211;35. http://dx.doi.org/10.1056/NEJMoa0911101. [PubMed]
5. Baillargeon J, Urban RJ, Ottenbacher KJ, et al. Trends in androgen prescribing in the United States, 2001 to 2011. JAMA Intern Med.2013;173:1465&#8211;6. http://dx.doi.org/10.1001/jamainternmed.2013.6895.[PubMed]
6. Bassil N, Alkaade S, Morley JE. The benefits and risks of testosterone replacement therapy: A review. Ther Clin Risk Manag. 2009;5:427&#8211;48.[PMC free article] [PubMed]
7. Nigro N, Christ-Crain M. Testosterone treatment in the aging male: myth or reality? Swiss Med Wkly. 2012;142:w13539. [PubMed]
8. Corona G, Mannucci E, Petrone L, et al. Psychobiological correlates of smoking in patients with erectile dysfunction. Int J Impot Res.2005;17:527&#8211;34. http://dx.doi.org/10.1038/sj.ijir.3901351. [PubMed]
9. Corona G, Rastrelli G, Balercia G, et al. Testosterone and cardiovascular risk in patients with erectile dysfunction. J Endocrinol Invest. 2012;35:809&#8211;16. [PubMed]
10. Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev.2005;26:833&#8211;76. http://dx.doi.org/10.1210/er.2004-0013. [PubMed]
11. Maggio M, Basaria S. Welcoming low testosterone as a cardiovascular risk factor. Int J Impot Res. 2009;21:261&#8211;4.http://dx.doi.org/10.1038/ijir.2009.25. [PMC free article] [PubMed]
12. Moncada I. Testosterone and men's quality of life. Aging Male.2006;9:189&#8211;93. http://dx.doi.org/10.1080/13685530601003180.[PubMed]
13. Snyder PJ, Peachey H, Berlin JA, et al. Effects of testosterone replacement in hypogonadal men. J Clin Endocrinol Metab.2000;85:2670&#8211;7. [PubMed]
14. Wang C, Alexander G, Berman N, et al. Testosterone replacement therapy improves mood in hypogonadal men--a clinical research center study. J Clin Endocrinol Metab. 1996;81:3578&#8211;83. [PubMed]
15. Wang C, Cunningham G, Dobs A, et al. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab. 2004;89:2085&#8211;98.http://dx.doi.org/10.1210/jc.2003-032006. [PubMed]
16. Yassin AA, Saad F. Improvement of sexual function in men with late-onset hypogonadism treated with testosterone only. J Sex Med.2007;4:497&#8211;501. http://dx.doi.org/10.1111/j.1743-6109.2007.00442.x.[PubMed]
17. Hackett G, Cole N, Bhartia M, et al. Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: The BLAST Study. J Sex Med. 2014;11:840&#8211;56. http://dx.doi.org/10.1111/jsm.12404. Epub 2013 Dec 6. [PubMed]
18. He J, Bhasin S, Binder EF, et al. Cardiometabolic risks during anabolic hormone supplementation in older men. Obesity (Silver Spring)2013;21:968&#8211;75. http://dx.doi.org/10.1002/oby.20081. [PMC free article][PubMed]
19. Corona G, Monami M, Rastrelli G, et al. Type 2 diabetes mellitus and testosterone: A meta-analysis study. Int J Androl. 2011;34:528&#8211;40.http://dx.doi.org/10.1111/j.1365-2605.2010.01117.x. [PubMed]
20. Basaria S, Coviello AD, Travison TG, et al. Adverse events associated with testosterone administration. N Engl J Med. 2010;363:109&#8211;22. http://dx.doi.org/10.1056/NEJMoa1000485. [PMC free article][PubMed]
21. Finkle W, Greenland S, Ridgeway G. Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men.PLoS One. 2014;9:e85805.http://dx.doi.org/10.1371/journal.pone.0085805. [PMC free article][PubMed]
22. Vigen R, O'Donnell CI, Baron AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013;310:1829&#8211;36.http://dx.doi.org/10.1001/jama.2013.280386. [PubMed]
23. Ramasamy R, Dupree JM, Kovac JR, et al. Risks of testosterone therapy in elderly men. F1000Research. 2014;3:11. [PMC free article][PubMed]
24. Xu L, Freeman G, Cowling BJ, et al. Testosterone therapy and cardiovascular events among men: A systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med. 2013;11:108.http://dx.doi.org/10.1186/1741-7015-11-108. [PMC free article][PubMed]
25. Chrysant SG. Effectiveness and safety of phosphodiesterase 5 inhibitors in patients with cardiovascular disease and hypertension. Curr Hypertens Rep. 2013;15:475&#8211;83. http://dx.doi.org/10.1007/s11906-013-0377-9. [PubMed]
26. Coviello AD, Kaplan B, Lakshman KM, et al. Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab. 2008;93:914&#8211;9. http://dx.doi.org/10.1210/jc.2007-1692. [PMC free article] [PubMed]
27. Ajayi AA, Mathur R, Halushka PV. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses.Circulation. 1995;91:2742&#8211;7.http://dx.doi.org/10.1161/01.CIR.91.11.2742. [PubMed]
28. Kunnas T, Solakivi T, Huuskonen K, et al. Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study, a 28-year follow-up. Prev Med. 2009;49:45&#8211;7.http://dx.doi.org/10.1016/j.ypmed.2009.04.015. [PubMed]
29. Sorlie PD, Garcia-Palmieri MR, Costas R, Jr, et al. Hematocrit and risk of coronary heart disease: The Puerto Rico Health Program. Am Heart J. 1981;101:456&#8211;61. http://dx.doi.org/10.1016/0002-8703(81)90136-8. [PubMed]
30. Yeap BB, Alfonso H, Chubb SA, et al. In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality. J Clin Endocrinol Metab.2014;99:E9&#8211;18. http://dx.doi.org/10.1210/jc.2013-3272. [PubMed]
31. Ramasamy R, Kovac JR, Scovell JM, et al. Re: In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality. Eur Urol.2014;65:844&#8211;5. http://dx.doi.org/10.1016/j.eururo.2013.12.030.[PubMed]




Articles from Canadian Urological Association Journal are provided here courtesy of Canadian Urological Association
 
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Nelson Vergel

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Testosterone therapy does not increase heart attack risk, study shows

Testosterone prescriptions for older men in the United States have increased more than three-fold over the past decade. Recent studies linking testosterone use with increased risk of heart attack and stroke have caused widespread concern among patients and their families. A new U.S.-based study of more than 25,000 older men shows that testosterone therapy does not increase men's risk for heart attack.

The study, conducted by researchers at the University of Texas Medical Branch at Galveston, examined 25,420 Medicare beneficiaries 66 years or older treated with testosterone for up to eight years. It appears in the July 2 issue of the Annals of Pharmacotherapy.

"Our investigation was motivated by a growing concern, in the U.S. and internationally, that testosterone therapy increases men's risk for cardiovascular disease, specifically heart attack and stroke," said Jacques Baillargeon, UTMB associate professor of epidemiology in the Department of Preventive Medicine and Community Health and lead author of the study. "This concern has increased in the last few years based on the results of a clinical trial and two observational studies," he said. "It is important to note, however, that there is a large body of evidence that is consistent with our finding of no increased risk of heart attack associated with testosterone use."

In recent years, the testosterone therapy market has grown to $1.6 billion annually as men seek to supplement low testosterone counts with products that may increase muscle tone and sex drive. Previous safety investigations presented conflicting findings. A few of these studies suggest testosterone is linked with increased risk of heart attack, although some critics have questioned the quality of these data. Doctors, researchers and government agencies all agree that more research into this issue is necessary.

The Food and Drug Administration decided June 20 to expand labeling on testosterone products to include a general warning about the risk of blood clots in veins. The FDA and European Medicines Agency are also further examining the safety of these products. This newest FDA warning comes shortly after the announcement that several testosterone treatment manufacturers, including Abbott Laboratories, AbbVie Inc., Eli Lilly and Company, Pfizer and Actavis, are facing a consolidated multidistrict litigation in Federal Court based on claims that they hid the risks of using testosterone treatments.

This new UTMB study evaluated enrollment and claims Medicare data for a clinically and socioeconomically diverse national sample treated with testosterone from 1997-2005. Men of the same age, race, Medicaid eligibility, and health status who did not receive testosterone therapy were used as a control group for comparison.

The analyses show that testosterone therapy was not associated with an increased risk of heart attack. Further, testosterone users with a higher probability of cardiovascular problems had a lower rate of heart attacks in comparison to equivalent patients who did not receive testosterone therapy.

"This is a rigorous analysis of a large number of patients," said Baillargeon. "Our findings did not show an increased risk of heart attack associated with testosterone use in older men," he said. "However, large&#8211;scale, randomized clinical trials will provide more definitive evidence regarding these risks in the coming years."
Provided by University of Texas Medical Branch at Galveston
 
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