1. #1
    Super Moderator Nelson Vergel's Avatar
    Join Date
    Sep 2013
    Location
    Houston, Texas, United States
    Posts
    2,547

    Botox Can Affect the Testicles

    Name:  botox.jpg
Views: 120
Size:  129.3 KB




    Highlights

    Botox injections are the trend nowadays, for both medical and non-medical uses.
    They were recently suggested for cryptorchidism and testicular spasms.
    This study outlines possible testicular adverse effects of these injections.
    Botox affected normal testicular function and physiology.
    Infertility is a serious problem that Botox injections could cause.


    Botox injections are taking a consistently increasing place in urology. Intracremasteric injections, particularly, have been applied for cryptorchidism and painful testicular spasms. Studies outlining their safety for this use are, however, scanty. Thus, the present study aimed at evaluating possible testicular toxicity of Botox injections and their effect on male fertility.


    Mature rats were given intracremasteric Botox injections (10, 20 and 40 U/kg) three times in a two-weeks interval. Changes in body and testes weights were examined and gonadosomatic index compared to control group. Semen quality, sperm parameters, fructose, protein, cholesterol and triglycerides contents were assessed. Effects on normal testicular function were investigated by measuring testosterone levels and changes in enzyme activities (lactate dehydrogenase-X and acid phosphatase). To draw a complete picture, changes in oxidative and inflammatory states were examined, in addition to extent of connective tissue deposition between semineferous tubules. In an attempt to have more accurate information about possible spermatotoxic effects of Botox, flowcytometric analysis and histopathological examination were carried out.


    Botox-injected rats showed altered testicular physiology and function. Semineferous tubules were separated by dense fibers, especially with the highest dose. Flowcytometric analysis showed a decrease in mature sperms and histopathology confirmed the findings. The oxidative state was, however, comparable to control group.


    This study is the first to show that intracremasteric injections of Botox induce adverse testicular effects evidenced by inhibited spermatogenesis and initiation of histopathological changes. In conclusion, decreased fertility may be a serious problem Botox injections could cause.

    Source

  2. # ADS
    Purchase From Our Affiliates
    Join Date
    Always
    Location
    Houston, TX
    Posts
    51
    Help Excelmale
     

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Google Analytics Alternative